Abstract

Delivery of gentamicin sulphate through the oral route has always been difficult because the drug is not permeable in the intestinal mucosa. There is hardly any oral preparation of this valuable drug effective for many gram-negative and gram-positive organisms. This work reviewed research works to aid achieve this systemic circulation of orally-administered gentamicin sulphate prepared with a natural oil. Natural oils have not only proven a great deal of source of bioactive phytochemicals but also can be a proven vehicle for oral preparations as they can confer some desirable antimicrobial synergism with conventional therapies. Various bioavailability studies of gentamicin sulphate were reviewed which revealed a great importance of a specialized formulation need that either enhances entrapment of the drug in a mix, sustained release formulation, or as solid-lipid microparticles e.t.c. These are all pharmaceutically possible and can be achieved using a natural oil as a vehicle plus permeation enhancers for such oral drug preparation.